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One challenge to its implementations that has been previously identi-?ed relates to existing power imbalances within a system’s organizational hierarchy(Gibson et al. In all infected nonunions, there is an area ofdead bone preventing fracture bridging and allowing persistence of infection. Some of the therapiesrely on the existing immune system of the patient to mount a response through administrationof defined tumor antigens/peptides with or without antigen presenting DCs or exogenous IL-2. (Reprinted with permissionfrom Hull BE,Staehelin LA.Functional significance ofthe variations in the geometrical organization oftightjunction networks.
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